The Hu lab is driven by a profound interest in unraveling the fundamental molecular intricacies governing biological macromolecules within organisms. Our research endeavors are firmly rooted in the quest to elucidate the molecular and cellular mechanisms orchestrating the assembly, regulation, and potential therapeutic applications of supramolecular complexes within immune systems.

​

Our primary research thrust revolves around the captivating world of CRISPR-Cas systems, which represent adaptive immunity systems deployed by prokaryotes to fend off viral invaders. This enthralling realm of study encompasses a spectrum of multifaceted projects that span a wide array of scientific inquiries. Our ongoing endeavors encompass, but are by no means confined to, the following areas:

​

1) Identificaion of novel CRISPR-Cas systems;

​

​

​

​

​

 

 

2) High-resolution mechanism study of supermolecular complexes.

​

​

​

​

 

3) Development and application of new genome-editing tools.

​

​

​

​

 

4) Diagnostic platform innovation based on CRISPR-Cas systems.

​

​

​

​

 

 

 

5) Therapeutic intervention based on gene-editing and RNA technologies.

​

​

​

​

 

 

6) Real-time reporter/imaging system exploring in cells.

​

​

​

​

 

 

7) Immunity beyond CRISPR.

​

​

​​

​

​

​

​

​

​

​